Level, 1 wins each over 2 singles meetings since 2024. Last meeting on 13/08/2025 at Cincinnati Open - Cincinnati.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 13/08/2025 | Cincinnati Open - Cincinnati | Round 4 | hard | Rune | 6-4 3-1 ret. |
| 19/08/2024 | Western & Southern Open - Cincinnati | Semi-final | hard | Tiafoe | 4-6 6-1 7-6(4) |
| hard | Tiafoe 1 - 1 Rune |
| 2025 | Tiafoe 0 - 1 Rune |
| 2024 | Tiafoe 1 - 0 Rune |
208 wins, 138 losses since 2021 (60.1%).
Last matches: D D D V D
249 wins, 128 losses since 2021 (66.0%).
Last matches: V D D V V
Level, 1 wins each over 2 singles meetings since 2024.
On 13/08/2025, at Cincinnati Open - Cincinnati (Round 4): Holger Rune won 6-4 3-1 ret..