Frances Tiafoe leads 4 to 3 over 7 singles meetings since 2021. Last meeting on 22/08/2026 at Cincinnati Open - Cincinnati.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 22/08/2026 | Cincinnati Open - Cincinnati | Quarter-final | hard | Tiafoe | 6-7(2) 5-7 |
| 03/06/2025 | French Open - Paris | Quarter-final | clay | Musetti | 6-2 4-6 7-5 6-2 |
| 15/08/2024 | Western & Southern Open - Cincinnati | Round 2 | hard | Tiafoe | 3-6 2-6 |
| 16/06/2023 | Boss Open - Stuttgart | Quarter-final | grass | Tiafoe | 7-6(6) 6-7(4) 2-6 |
| 15/05/2023 | Internazionali BNL d'Italia - Rome | Round 3 | clay | Musetti | 5-7 6-4 5-3 |
| 08/01/2023 | United Cup - Australia | Final | hard | Tiafoe | 4-2 |
| 18/03/2021 | Abierto Mexicano Telcel - Acapulco | Round 2 | hard | Musetti | 2-6 6-3 7-6(1) |
| hard | Tiafoe 3 - 1 Musetti |
| clay | Tiafoe 0 - 2 Musetti |
| grass | Tiafoe 1 - 0 Musetti |
| 2026 | Tiafoe 1 - 0 Musetti |
| 2025 | Tiafoe 0 - 1 Musetti |
| 2024 | Tiafoe 1 - 0 Musetti |
| 2023 | Tiafoe 2 - 1 Musetti |
| 2021 | Tiafoe 0 - 1 Musetti |
204 wins, 133 losses since 2021 (60.5%).
Last matches: V V V D V
223 wins, 146 losses since 2021 (60.4%).
Last matches: D V D V V
Frances Tiafoe leads 4 to 3 over 7 singles meetings since 2021.
On 22/08/2026, at Cincinnati Open - Cincinnati (Quarter-final): Frances Tiafoe won 6-7(2) 5-7.