Stefanos Tsitsipas leads 5 to 2 over 7 singles meetings since 2021. Last meeting on 27/04/2025 at Mutua Madrid Open - Madrid.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 27/04/2025 | Mutua Madrid Open - Madrid | Round 3 | clay | Musetti | 5-7 6-7(3) |
| 11/04/2025 | Monte-Carlo Rolex Masters - Monte-Carlo | Quarter-final | clay | Musetti | 1-6 6-3 6-4 |
| 16/05/2023 | Internazionali BNL d'Italia - Rome | Round 4 | clay | Tsitsipas | 7-5 7-5 |
| 22/04/2023 | Barcelona Open Banc Sabadell - Barcelona | Semi-final | clay | Tsitsipas | 4-6 7-5 3-6 |
| 22/05/2022 | French Open - Paris | Round 1 | clay | Tsitsipas | 7-5 6-4 2-6 3-6 2-6 |
| 22/05/2021 | Open Parc - Lyon | Semi-final | clay | Tsitsipas | 6-4 3-6 0-6 |
| 20/03/2021 | Abierto Mexicano Telcel - Acapulco | Semi-final | hard | Tsitsipas | 6-1 6-3 |
| clay | Tsitsipas 4 - 2 Musetti |
| hard | Tsitsipas 1 - 0 Musetti |
| 2025 | Tsitsipas 0 - 2 Musetti |
| 2023 | Tsitsipas 2 - 0 Musetti |
| 2022 | Tsitsipas 1 - 0 Musetti |
| 2021 | Tsitsipas 2 - 0 Musetti |
256 wins, 122 losses since 2021 (67.7%).
Last matches: V V V D V
223 wins, 146 losses since 2021 (60.4%).
Last matches: D V D V V
Stefanos Tsitsipas leads 5 to 2 over 7 singles meetings since 2021.
On 27/04/2025, at Mutua Madrid Open - Madrid (Round 3): Lorenzo Musetti won 5-7 6-7(3).